EXTRAPANCREATIC EFFECTS OF SULFONYLUREA DRUGS

Authors
KAKU K INOUE Y KANEKO T
Citation
K. Kaku et al., EXTRAPANCREATIC EFFECTS OF SULFONYLUREA DRUGS, Diabetes research and clinical practice, 28, 1995, pp. 105-108
Citations number
21
Categorie Soggetti
Gastroenterology & Hepatology","Endocrynology & Metabolism
Journal title
Diabetes research and clinical practice → ACNP
ISSN journal
01688227
Volume
28
Year of publication
1995
Supplement
S
Pages
105 - 108
Database
ISI
SICI code
0168-8227(1995)28:<105:EEOSD>2.0.ZU;2-6
Abstract
Extrapancreatic action of sulfonylurea (SU) drugs were extensively sum marized. Hypoglycemic SU drugs stimulate glycolytic pathway and inhibi t gluconeogenic pathway in the liver through regulating key enzymes su ch as the bifunctional enzyme PFK2/F-2,6-P(2)ase and PEPCK. It is poss ible that SUs improve the primary defects in NIDDM through both pancre atic and extrapancreatic actions.