CHOLESTASIS INDUCED BY HYPERTHYROIDISM AFTER LIVER-TRANSPLANTATION

We report the case of a 68-year-old woman who underwent liver transpla ntation because of hepatitis-C-induced cirrhosis. She developed iodine -induced hyperthyroidism postoperatively in temporal relation with cho lestatic jaundice. Hepatic biopsies revealed moderate intrahepatic cho lestasis and mild lobular inflammatory infiltration with some eosinoph ils. No histological evidence of acute graft rejection or reactivated hepatitis was found. Treatment with methimazole markedly reduced the s erum parameters of cholestasis which, after subtotal thyroidectomy, re turned to normal. Liver function recovered, as confirmed by repeated a minopyrine breath tests.