A SIMPLE METHOD FOR MEASURING GLOMERULAR-FILTRATION RATE IN DOGS

A technique for measuring glomerular filtration rate (by six-sample pl asma clearance) and extracellular fluid volume is described. The resul ts obtained for glomerular filtration rate per extracellular fluid vol ume with a three blood sample technique are also presented. Concurrent ly with the blood sample techniques measuring plasma clearance, glomer ular filtration rate per extracellular fluid volume was also measured using an external radiation detector and no blood samples. The validit y of expressing glomerular filtration rate per extracellular fluid vol ume (rather than per body weight or surface area) and the clinical uti lity of the results obtained with the external radiation detector are discussed.