Jg. Pereiralima et al., HELICOBACTER-PYLORI-ASSOCIATED GASTRITIS - DOES IT PLAY A ROLE IN FUNCTIONAL DYSPEPSIA, Zeitschrift fur Gastroenterologie, 33(8), 1995, pp. 421-425
Objectives: The goal of this study is to averiguate whether Helicobact
er pylori (Hp)-associated gastritis is involved in the etiology of fun
ctional dyspepsia (FD) or, at least in a subset of these patients. Met
hods: 103 consecutive FD patients were prospectively analyzed and subd
ivided according to their main complaints into ulcer-like FD (n = 31),
dysmotility-like FD (n = 24) or nonspecific FD (n = 48). After endosc
opy with gastric biopsy, gastritis and Hp infection were assessed and
graded by histology according to the Sydney System. The prevalence of
gastritis, Hp and disease activity were analyzed among the three FD su
btypes and against 42 age, sex and race matched controls. Results: Hp
was identified in 64 (62%) of the FD group and in 23 (55%) of the cont
rols (p > 0.20, NS). We neither observed any increased prevalence of t
he infection among FD subgroups (dysmotility-like 58%, ulcer-like 58%,
unspecified 67%), nor in the activity of gastritis among FD subgroups
and controls. We conclude that Helicobacter pylori gastritis per se i
s not associated with functional dyspepsia.