HEAT STABILIZED, INFECTIOUS POLIOVIRUS

Authors
OFORIANYINAM O VRIJSEN R KRONENBERGER P BOEYE A
Citation
O. Oforianyinam et al., HEAT STABILIZED, INFECTIOUS POLIOVIRUS, Vaccine, 13(11), 1995, pp. 983-986
Citations number
20
Categorie Soggetti
Immunology
Journal title
Vaccine → ACNP
ISSN journal
0264410X
Volume
13
Issue
11
Year of publication
1995
Pages
983 - 986
Database
ISI
SICI code
0264-410X(1995)13:11<983:HSIP>2.0.ZU;2-H
Abstract
Polioviruses type 1 (Mahoney) and type 3 (Sabin) were treated with the antiviral pyridazinamine R78206 by first binding the compound to the virus and then removing unbound compound by dialysis. As a result of t his treatment, both poliovirus strains were protected against thermal inactivation at 46 degrees C. The R78206 treatment did not cause inact ivation except with the Sabin 3 strain at high R78206 concentrations.