THE EFFECTS OF VACCINATION WITH INACTIVATED UROPATHOGENIC BACTERIA INRECURRENT URINARY-TRACT INFECTIONS OF CHILDREN

Secretory IgA (sIgA) is an important parameter in the predisposition t o recurrent urinary tract infection (UTI). We investigated whether sIg A and frequency of UTI could be positively influenced by intramuscular vaccination with inactivated uropathogenic bacteria (Solco-Urovac). T en otherwise healthy girls aged from 5 to 11 years (mean 9 +/- 1.7 yea rs) with recurrent UTI were immunized with Solco-Urovac by i.m. inject ions three times at weekly intervals. A booster injection was given af ter 6 months. Urinary sIgA secretory component (SC) concentration was determined by radial immunodiffusion assay. Ten other age-matched girl s with UTI were not immunized. Immunization therapy caused a significa nt reduction in the frequency of infection and an increase in urinary sIgA SC, while in the nonvaccinated group the values remained constant .