ENHANCED IN-VIVO PERFORMANCE OF LIPOSOMAL INDOMETHACIN DERIVED FROM EFFERVESCENT GRANULE BASED PROLIPOSOMES

Indomethacin, a non-steroidal anti-inflammatory drug was successfully entrapped into liposomes (soyabean lecithin, cholesterol, stearylamine or dicetylphosphate) with uniform size distribution. The liposomal ve sicles were derived from dried effervescent granule-based proliposomes . The in vivo distribution characteristics of the reconstituted liposo mal indomethacin was studied in normal rats and in the rats with infla med paws following intravenous administration. The localization of the liposome-based indomethacin was in liver, lungs and inflamed tissues (inflamed rats studies). Further, an enhanced anti-inflammatory activi ty of lipo-indomethacin was found as compared with the activity record ed for plain drug in carrageenan induced paw oedema in rats.