E. Demiguel et al., SOMATOSTATIN AND GROWTH-HORMONE IN THE IN TESTINAL POSTCOLECTOMY HIPERPLASIA IN THE RAT, Revista espanola de enfermedades digestivas, 87(8), 1995, pp. 569-573
Aim: Somatostatin exerts significant effects on gastrointestinal funct
ion that may include mucosal growth regulation, probably through its a
ction on growth hormone release. The aim of this work was to correlate
somatostatin and growth hormone plasma levels and the hyperproliferat
ive status of intestinal mucosa after colectomy. Experimental design:
Adult Wistar rats were divided into two groups: control sham operated
(n = 8) and large bowel resection (n = 8). Seven days post-colectomy,
the animals were killed. Ileal mucosal samples were assayed for prolif
erative status (morphometry, and proliferating cell nuclear antigen la
beling) and blood samples for plasmatic somatostatin and growth hor-mo
ne measurement. Results: A hyperproliferative status was observed with
significant increases in villous length and crypt proliferating cell
nuclear antigen labeling. Plasma somatostatin showed a 95% significant
decrease while growth hormone levels increased significantly. Conclus
ion: The intestinal adaptation seen after colectomy is associated with
lower somatostatin and higher growth hormone plasma level, possibly b
y regulating the intestinal adaptative process.