ANTIFUNGAL COMBINATION THERAPY WITH GRANULOCYTE-COLONY-STIMULATING FACTOR AND FLUCONAZOLE IN EXPERIMENTAL DISSEMINATED CANDIDIASIS

The present studies were performed to determine whether any beneficial interaction results from combination therapy with recombinant human g ranulocyte colony-stimulating factor (GCSF) and fluconazole in dissemi nated candidiasis in mice. Fluconazole extended survival and reduced t issue counts. GCSF had no direct benefit, but GCSF combined with fluco nazole extended survival beyond that for fluconazole alone and reduced renal tissue counts below those for fluconazole alone. Thus, GCSF and fluconazole may be a useful combined therapy for disseminated candidi asis.