THROMBOLYSIS OF PERIPHERAL GRAFT OCCLUSION IN PATIENTS WITH HYPERTENSION

The objective of this study was to evaluate the effect of hypertension on the use of thrombolytic therapy in patients with occluded syntheti c peripheral bypass grafts, Thrombolysis with urokinase was performed in 44 cases of occluded lower extremity bypass grafts, The cases were divided into two groups: Group I consisted of patients currently being treated for hypertension, Group II consisted of patients without a hi story of hypertension, A comparison of pre- or intra-lytic data reveal ed that there was no significant difference in each group, Complicatio ns occurred in 15 (32.6%) out of 46 cases, There was no significant in crease in complication when the risk factors were compared, In Group I , the one, two, and three year patency rates were 42.7%, 23.0%, and 7. 7% and the limb salvage rates were 93.3%, 73.9%, and 73.9% for one, tw o, and three years respectively, The Group II patency rates were 70.6% , 41.6%, and 41.6% and the limb salvage rates were 94.1%, 86.9%, and 8 6.9%. The patency rate was significantly reduced when Group I was comp ared to Group II (p<0.05), There was no statistically significant diff erence in limb salvage rates between Groups I and II, In conclusion, h ypertension is one of the important risk factors that reduce the paten cy rate after thrombolytic therapy in patients with peripheral arteria l bypass graft.