Eight patients receiving electroconvulsive therapy (ECT) were anesthet
ized with alfentanil, 25 mcg/kg, plus 20 mg methohexital, alternating
with standard methohexital anesthesia. Combination alfentanil-methohex
ital anesthesia was associated with a 45% increase in EEG seizure dura
tion. preliminary evidence suggests that ECT anesthesia using short-ac
ting opiate compounds may prove to be a promising alternative to stand
ard modified ECT, especially for patients with brief seizures.