Cg. Cowan et al., LINEAR IGA DISEASE (LAD) - IMMUNOGLOBULIN DEPOSITION IN ORAL AND COLONIC LESIONS, Journal of oral pathology & medicine, 24(8), 1995, pp. 374-378
Two cases of adult linear IgA disease (LAD) with oral and colonic invo
lvement are presented. Oral findings, for both patients, were of wides
pread painful ulceration present for two to three months and diagnosis
was confirmed by biopsy and direct immunofluorescence. Colonic sympto
ms preceded oral symptoms in both cases and a number of investigations
were undertaken, including routine histological examination, which su
ggested either lymphocytic colitis or Crohn's disease. Immunofluoresce
nce studies showed linear IgA deposition confined to the distal colon.
These cases highlight that large bowel involvement can be a feature o
f linear IgA disease and for the first time demonstrate IgA deposition
at that site.