LINEAR IGA DISEASE (LAD) - IMMUNOGLOBULIN DEPOSITION IN ORAL AND COLONIC LESIONS

Two cases of adult linear IgA disease (LAD) with oral and colonic invo lvement are presented. Oral findings, for both patients, were of wides pread painful ulceration present for two to three months and diagnosis was confirmed by biopsy and direct immunofluorescence. Colonic sympto ms preceded oral symptoms in both cases and a number of investigations were undertaken, including routine histological examination, which su ggested either lymphocytic colitis or Crohn's disease. Immunofluoresce nce studies showed linear IgA deposition confined to the distal colon. These cases highlight that large bowel involvement can be a feature o f linear IgA disease and for the first time demonstrate IgA deposition at that site.