PROLIFERATIVE ACTIVITY IN METASTATIC MALIGNANT-MELANOMA - COMPARISON OF PRETREATMENT AND POSTTREATMENT METASTASES

Authors
BARKSDALE SK STERN JB HAUPT HM MULTHAUPT H
Citation
Sk. Barksdale et al., PROLIFERATIVE ACTIVITY IN METASTATIC MALIGNANT-MELANOMA - COMPARISON OF PRETREATMENT AND POSTTREATMENT METASTASES, Journal of cutaneous pathology, 22(4), 1995, pp. 354-358
Citations number
29
Categorie Soggetti
Pathology,"Dermatology & Venereal Diseases
Journal title
Journal of cutaneous pathology → ACNP
ISSN journal
03036987
Volume
22
Issue
4
Year of publication
1995
Pages
354 - 358
Database
ISI
SICI code
0303-6987(1995)22:4<354:PAIMM->2.0.ZU;2-4
Abstract
In this study, the proliferative activity of malignant melanoma metast ases was assessed before and after isolated limb perfusion chemotherap y by quantitating AgNORs, mitoses and PCNA activity. No significant di fference in either AgNOR count, mitotic activity or PCNA index was obs erved. We conclude that AgNOR count, mitotic activity and PCNA index w ere not significantly effected by isolated limb perfusion chemotherapy .