ENZYME-IMMUNOASSAY OF NEUROSPECIFIC PROTE INS IN THE SERUM OF EPILEPTIC PATIENTS

Serum levels of glyofibrillar acid protein (GFAP), alpha-2 glycoprotei n (A2GP), alpha-1 brain globulin (A1BG), alpha-2 brain globulin (A2BG) were measured in 41 epileptic patients (2 groups - with convulsive an d nonconvulsive forms of the disease) with the help of ''sandwich'' va riant of enzyme immunoassay and double-centered enzyme immunoassay on the basis of column immunosorption chromatography. Investigations were performed in the interval from the first to the 30th day after the fi t. The level of at least one of neurospecific proteins was elevated in 65,2% of patients. The same changes were revealed in one third of pat ients during the period of 30 days. Frequency discovering of A1BG as c ompared to A2GP was significantly lower only in patients with convulsi ve epilepsy. It allowed the authors to suggest, that serum antigenic l evels in patients with various forms of epilepsy were different.