Fy. Huang et al., COLORADO POTATO BEETLE ANTIFEEDANTS BY SIMPLE MODIFICATION OF THE BIRCHBARK TRITERPENE BETULIN, Journal of agricultural and food chemistry, 43(9), 1995, pp. 2513-2516
Oxidation of the 19-side-chain of betulin 3 beta,28-diacetate, a penta
cyclic triterpene derived from the readily available birchbark triterp
ene, betulin, yielded compounds active as antifeedants against larvae
of the agricultural insect pest Colorado potato beetle, Leptinotarsa d
ecemlineata. Of the eight compounds investigated, the most active was
30-hydroxy-20-oxo-29-norlup-3 beta,28-diacetate (VI). Acetylation of V
I significantly reduced antifeedant activity.