INHIBITORS OF GLUCOSIDASES WITH RELATED STRUCTURES AND INVERSE SPECIFICITY

Authors
THERISOD M THERISOD H LUBINEAU A
Citation
M. Therisod et al., INHIBITORS OF GLUCOSIDASES WITH RELATED STRUCTURES AND INVERSE SPECIFICITY, Bioorganic & medicinal chemistry letters, 5(18), 1995, pp. 2055-2058
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
18
Year of publication
1995
Pages
2055 - 2058
Database
ISI
SICI code
0960-894X(1995)5:18<2055:IOGWRS>2.0.ZU;2-5
Abstract
A dinitrophenyl ether (III) of gluconolactone oxime I was synthesized and tested as an inhibitor of glucosidases. Surprisingly, in contrast to the known compound II, III was found to be a modest inhibitor of be ta-glucosidase, but a good inhibitor of alpha-glucosidase (Ki = 5 mu M ).