PROCTOLIN AND RELATED N-METHYLATED PENTAPEPTIDES SELECTIVELY CONTRACTLOCUST FOREGUT BUT NOT RAT ILEUM

Authors
OSBORNE RH ODELL B BLAGBROUGH IS
Citation
Rh. Osborne et al., PROCTOLIN AND RELATED N-METHYLATED PENTAPEPTIDES SELECTIVELY CONTRACTLOCUST FOREGUT BUT NOT RAT ILEUM, Bioorganic & medicinal chemistry letters, 5(18), 1995, pp. 2085-2088
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
18
Year of publication
1995
Pages
2085 - 2088
Database
ISI
SICI code
0960-894X(1995)5:18<2085:PARNPS>2.0.ZU;2-C
Abstract
Proctolin contracts locust, but contrary to a previous report, not rat gut tissue, in a dose-dependent manner. [N-Me-Thr]- and [N-Me-Leu]-, but not [N-Me-Tyr]-proctolin were also agonists on locust foregut. We propose that proctolin contains a trans-Pro and exists in a cyclic con formation based upon solution NMR studies.