5,6,7,8-TETRAHYDROQUINOLONES AS ANTAGONISTS AT THE GLYCINE SITE OF THE NMDA RECEPTOR

Authors
ROWLEY M LEESON P GRIMWOOD S MARSHALL G SAYWELL K
Citation
M. Rowley et al., 5,6,7,8-TETRAHYDROQUINOLONES AS ANTAGONISTS AT THE GLYCINE SITE OF THE NMDA RECEPTOR, Bioorganic & medicinal chemistry letters, 5(18), 1995, pp. 2089-2092
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
18
Year of publication
1995
Pages
2089 - 2092
Database
ISI
SICI code
0960-894X(1995)5:18<2089:5AAATG>2.0.ZU;2-5
Abstract
The effect of reducing the benzo ring of a series of 4-hydroxyquinolon e Glycine/NMDA antagonists is described. It is important that the ring be present, but not that it is aromatic. Provided that the correct li pophilic interactions are present, high affinity is found in 4-hydroxy -5,6,7,8 -tetrahydroquinolones.