RS-100235 - A HIGH-AFFINITY 5-HT4 RECEPTOR ANTAGONIST

Authors
CLARK RD JAHANGIR A FLIPPIN LA LANGSTON JA LEUNG E BONHAUS DW WONG EHF JOHNSON LG EGLEN RM
Citation
Rd. Clark et al., RS-100235 - A HIGH-AFFINITY 5-HT4 RECEPTOR ANTAGONIST, Bioorganic & medicinal chemistry letters, 5(18), 1995, pp. 2119-2122
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
18
Year of publication
1995
Pages
2119 - 2122
Database
ISI
SICI code
0960-894X(1995)5:18<2119:R-AH5R>2.0.ZU;2-6
Abstract
The 1,4-benzodioxanyl ketone 14 (RS-100235) was found to be high affin ity 5-HT4 antagonist with potent in vivo activity and a sustained dura tion of action in the anesthetized pig.