INCREASING THE CELLULAR PKC INHIBITORY ACTIVITY OF BALANOL - A STUDY OF ESTER ANALOGS

Authors
CRANE HM MENALDINO DS JAGDMANN GE DARGES JW BUBEN JA
Citation
Hm. Crane et al., INCREASING THE CELLULAR PKC INHIBITORY ACTIVITY OF BALANOL - A STUDY OF ESTER ANALOGS, Bioorganic & medicinal chemistry letters, 5(18), 1995, pp. 2133-2138
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
18
Year of publication
1995
Pages
2133 - 2138
Database
ISI
SICI code
0960-894X(1995)5:18<2133:ITCPIA>2.0.ZU;2-B
Abstract
As part of an effort to enhance the cellular activity of balanol analo gs 2 and 3, we prepared a series of benzophenone ester analogs of vary ing steric size and hydrolytic stability. These were evaluated for pro tein kinase C inhibitory activity, with the results showing that both small alkyl esters and the pivaloyloxymethyl ester analogs displayed l arge increases in cellular PKC inhibition.