SYNTHETIC INHIBITORS OF INTERLEUKIN-6 .1. YL-1H-CYCLOPENT[E]IMIDAZO[1,2-A]-PYRIDIN-5(6H)-ONE AND RELATED-COMPOUNDS

Authors
TAGAT JR NAZARENO DV MCCOMBIE SW BARTON BE SHORTALL J JACKSON J
Citation
Jr. Tagat et al., SYNTHETIC INHIBITORS OF INTERLEUKIN-6 .1. YL-1H-CYCLOPENT[E]IMIDAZO[1,2-A]-PYRIDIN-5(6H)-ONE AND RELATED-COMPOUNDS, Bioorganic & medicinal chemistry letters, 5(18), 1995, pp. 2139-2142
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
18
Year of publication
1995
Pages
2139 - 2142
Database
ISI
SICI code
0960-894X(1995)5:18<2139:SIOI.Y>2.0.ZU;2-L
Abstract
A versatile synthetic route to the title class of compounds and the de velopment of an orally absorbed analogue of the lead structure are des cribed. The minimum structural requirements needed in the compounds re lated to 1 for the inhibition of interleukin-6 were identified.