SYNTHETIC INHIBITORS OF INTERLEUKIN-6 .2. 3,5-DIARYL PYRIDINES AND META-TERPHENYLS

Authors
TAGAT JR MCCOMBIE SW BARTON BE JACKSON J SHORTALL J
Citation
Jr. Tagat et al., SYNTHETIC INHIBITORS OF INTERLEUKIN-6 .2. 3,5-DIARYL PYRIDINES AND META-TERPHENYLS, Bioorganic & medicinal chemistry letters, 5(18), 1995, pp. 2143-2146
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
18
Year of publication
1995
Pages
2143 - 2146
Database
ISI
SICI code
0960-894X(1995)5:18<2143:SIOI.3>2.0.ZU;2-6
Abstract
An efficient synthesis of the title compounds using the Ni (II) cataly sed coupling of various aryl magnesium bromides with di-halo pyridines and di-halo benzenes is reported. Among the several compounds tested, 1, 2, 12 and 17 showed good inhibitory activity against interleukin-6 .