RING SIZE EFFECT IN THE PKC INHIBITORY ACTIVITIES OF PERHYDROAZEPINE ANALOGS OF BALANOL

Authors
LAI YS MENALDINO DS NICHOLS JB JAGDMANN GE MYLOTT F GILLESPIE J HALL SE
Citation
Ys. Lai et al., RING SIZE EFFECT IN THE PKC INHIBITORY ACTIVITIES OF PERHYDROAZEPINE ANALOGS OF BALANOL, Bioorganic & medicinal chemistry letters, 5(18), 1995, pp. 2151-2154
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
18
Year of publication
1995
Pages
2151 - 2154
Database
ISI
SICI code
0960-894X(1995)5:18<2151:RSEITP>2.0.ZU;2-1
Abstract
Analogs 3-5 of balanol (-)-1, a potent protein kinase C (PKC) inhibito r, were synthesized with the perhydroazepine moiety replaced by a smal ler ring. Their in vitro inhibitory activities against PKC revealed a significant relationship between ring size and potency.