SYNTHESIS AND PKC INHIBITORY ACTIVITIES OF BALANOL ANALOGS WITH A CYCLOPENTANE SUBSTRUCTURE

Authors
LAI YS MENDOZA JS HUBBARD F KALTER K
Citation
Ys. Lai et al., SYNTHESIS AND PKC INHIBITORY ACTIVITIES OF BALANOL ANALOGS WITH A CYCLOPENTANE SUBSTRUCTURE, Bioorganic & medicinal chemistry letters, 5(18), 1995, pp. 2155-2160
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
18
Year of publication
1995
Pages
2155 - 2160
Database
ISI
SICI code
0960-894X(1995)5:18<2155:SAPIAO>2.0.ZU;2-O
Abstract
Compounds 4-7, analogs of the potent protein kinase C (PKC) inhibitor balanol (-)-1, were synthesized and their potency against PKC was comp ared with racemic balanol and other related analogs. These cyclopentan e-based analogs were found to be, in general, more potent PKC inhibito rs than balanol.