EFFECT OF GLOMERULAR CELLS INTERACTION WITH MACROPHAGES ON SURFACE 5'-NUCLEOTIDASE ACTIVITY

Interaction of cultured rat mesangial cells with macrophages induces a marked increase in surface 5'-nucleotidase activity of these mesangia l cells. A significant increase in surface 5'-nucleotidase was also ob served upon interaction of rat fibroblast with macrophages, both in co cultures and after treatment of fibroblasts with macrophage conditione d medium. Interaction of glomerular epithelial cells in primary cultur e with macrophages had pro effect on surface 5'-nucleotidase activity. No significant effect on enzyme activity was observed after interacti on of mesangial - epithelial cells, mesangial cells - fibroblasts, and epithelial cells - fibroblasts.