ENANTIOSELECTIVE SYNTHESIS OF A HALICHONDRIN-B C(20)-]C(36) PRECURSOR

Authors
BURKE SD ZHANG G BUCHANAN JL
Citation
Sd. Burke et al., ENANTIOSELECTIVE SYNTHESIS OF A HALICHONDRIN-B C(20)-]C(36) PRECURSOR, Tetrahedron letters, 36(39), 1995, pp. 7023-7026
Citations number
43
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
39
Year of publication
1995
Pages
7023 - 7026
Database
ISI
SICI code
0040-4039(1995)36:39<7023:ESOAHC>2.0.ZU;2-U
Abstract
Differential functionalization of the nearly symmetrical bis(dihydropy ran)3 is described leading to the C(20)-->C(36) holichondrin B precurs or 1. Double hydroboration, regioselective mono-protection of the resu lting diol and two-directional chain extension are featured