ASYMMETRIC-SYNTHESIS OF (2S,3R) BETA-(4-F-3-NO2) PHENYL SERINE, D-(R)-4-METHOXY-3,5-BIS(T)BUTYLDIMETHYLSILOXY PHENYLGLYCINE AND THEIR ASSEMBLAGE TO C-O-D RING OF VANCOMYCIN

The asymmetric synthesis of two appropriately functionalized non-prote inogenic amino acids 2 and 3 needed for the total synthesis of vancomy cin was described. The assemblage of these amino acids into linear tri peptide followed by biaryl ether formation via intramolecular SNAr rea ction led to the fully functionalized C-O-D ring of vancomycin.