P. Beltes et al., IN-VITRO EVALUATION OF THE CYTOTOXICITY OF CALCIUM HYDROXIDE-BASED ROOT-CANAL SEALERS, Endodontics & dental traumatology, 11(5), 1995, pp. 245-249
The cytotoxicity of three calcium hydroxide-containing root canal seal
ers (Sealapex, CRCS and Apexit) was tested by using L929 and BHK 21/C1
3 cells. After setting for 24h, the sealers were covered with cell sus
pension. Cytotoxicity was determined by a quantitative technique at 24
h, 48h and 72h. All the sealers were found to be cytotoxic. Sealapex s
howed the highest cytotoxicity, causing a significant decrease in cell
density. CRCS was less toxic than Sealapex and more toxic than Apexit
. Apexit proved to be the least toxic material.