IDENTIFICATION OF THE HUMAN NEURONAL NICOTINIC CHOLINERGIC ALPHA-2 RECEPTOR LOCUS, (CHRNA2), WITHIN AN 8P21 MAPPED LOCUS, BY SEQUENCE HOMOLOGY WITH RAT DNA

Authors
WOOD S SCHERTZER M YAREMKO ML
Citation
S. Wood et al., IDENTIFICATION OF THE HUMAN NEURONAL NICOTINIC CHOLINERGIC ALPHA-2 RECEPTOR LOCUS, (CHRNA2), WITHIN AN 8P21 MAPPED LOCUS, BY SEQUENCE HOMOLOGY WITH RAT DNA, Somatic cell and molecular genetics, 21(2), 1995, pp. 147-150
Citations number
12
Categorie Soggetti
Cell Biology","Genetics & Heredity",Biology
Journal title
Somatic cell and molecular genetics → ACNP
ISSN journal
07407750
Volume
21
Issue
2
Year of publication
1995
Pages
147 - 150
Database
ISI
SICI code
0740-7750(1995)21:2<147:IOTHNN>2.0.ZU;2-O
Abstract
We have identified a cosmid, at the D8S131 locus, that shows sequence homology with exon 2 of the rat gene for the neuronal nicotinic acetyl choline receptor alpha 2 subunit. A 357-bp sequence surrounding a rave cutter AscI site contains a 152-bp region of homology. The human CHRN A2 gene is therefore positioned at the D8S131 focus, which has been ma pped to 8p21.