PROLACTIN-INDUCED ANALGESIA IS DEPENDENT ON ATP-SENSITIVE POTASSIUM CHANNELS

Authors
SHEWADE DG RAMASWAMY S
Citation
Dg. Shewade et S. Ramaswamy, PROLACTIN-INDUCED ANALGESIA IS DEPENDENT ON ATP-SENSITIVE POTASSIUM CHANNELS, Clinical and experimental pharmacology and physiology, 22(9), 1995, pp. 635-636
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Physiology
Journal title
Clinical and experimental pharmacology and physiology → ACNP
ISSN journal
03051870
Volume
22
Issue
9
Year of publication
1995
Pages
635 - 636
Database
ISI
SICI code
0305-1870(1995)22:9<635:PAIDOA>2.0.ZU;2-D
Abstract
1. The role of ATP sensitive potassium channels in the analgesic activ ity of prolactin (PRL) was studied in mice using glibenclamide and min oxidil, a blocker and an opener of these channel, respectively. 2. Pre -treatment with glibenclamide attenuated the analgesic activity of PRL while treatment with minoxidil potentiated the activity. 3. It is con cluded that PRL, similar to morphine, utilizes ATP sensitive potassium channels in eliciting the analgesic response.