Dg. Shewade et S. Ramaswamy, PROLACTIN-INDUCED ANALGESIA IS DEPENDENT ON ATP-SENSITIVE POTASSIUM CHANNELS, Clinical and experimental pharmacology and physiology, 22(9), 1995, pp. 635-636
1. The role of ATP sensitive potassium channels in the analgesic activ
ity of prolactin (PRL) was studied in mice using glibenclamide and min
oxidil, a blocker and an opener of these channel, respectively. 2. Pre
-treatment with glibenclamide attenuated the analgesic activity of PRL
while treatment with minoxidil potentiated the activity. 3. It is con
cluded that PRL, similar to morphine, utilizes ATP sensitive potassium
channels in eliciting the analgesic response.