The mineralocorticoid-excess state caused by primary aldosteronism usu
ally causes hypokalemia and moderate to severe hypertension. A directe
d approach to the patient with suspected primary aldosteronism is esse
ntial. Appropriate use of biochemical and diagnostic imaging studies c
an identify the etiology of the primary aldosteronism in an efficient
and noninvasive way in most cases. Precision in defining the etiology
of the mineralocorticoid-excess state logically leads to therapeutic s
trategies that usually cure or improve the hypertensive state.