PERSISTENCE OF KINDLING - EFFECT OF PARTIAL KINDLING, RETENTION INTERVAL, KINDLING SITE, AND STIMULATION PARAMETERS

Citation
Z. Dennison et al., PERSISTENCE OF KINDLING - EFFECT OF PARTIAL KINDLING, RETENTION INTERVAL, KINDLING SITE, AND STIMULATION PARAMETERS, Epilepsy research, 21(3), 1995, pp. 171-182
Citations number
23
Categorie Soggetti
Clinical Neurology
Journal title
ISSN journal
09201211
Volume
21
Issue
3
Year of publication
1995
Pages
171 - 182
Database
ISI
SICI code
0920-1211(1995)21:3<171:POK-EO>2.0.ZU;2-1
Abstract
The kindling effect is generally thought to be highly persistent and p ossibly permanent, but little direct evidence is available to support this idea. Retention of amygdala kindling was examined after a 12-wk i nterval in groups of rats that had been electrically kindled to differ ent seizure stages (stages 1, 3, or 5), or kindled by high intensity o r low frequency (3 pulses per second) stimulation, or fully kindled an d allowed a rest of 1-24 wk. The retention of hippocampal kindling aft er a 12-wk interval was also examined. Rekindling after a 12-wk rest i n the groups initially kindled to different seizure stages indicated t hat although there was evidence of erosion of the kindling effect in a ll groups, there were savings in all groups. There was also evidence o f greater erosion in the afterdischarge response than in the convulsiv e response to the first stimulation after the interval. Although there was evidence of erosion of kindling during the 1-24-wk intervals, the re was evidence of savings in all groups, none of which required more than a mean of 2.2 afterdischarges to rekindle to stage 5. Seizures ki ndled in the hippocampus were retained as well as those kindled in the amygdala, and seizures kindled using low frequency stimulation were r etained as well as those kindled using conventional 60 pulses per seco nd stimulation. We conclude that the effects of kindling the amygdala and hippocampus are highly persistent, and that the effects of kindlin g with low frequency stimulation are as persistent as kindling with co nventional stimulation.