THE STICKY SECRETS OF SEQUESTRATION

Sequestration, the adherence of infected erythrocytes containing the m ore mature stages of parasite development (trophozoites and schizonts) to the endothelial cells lining the capillaries and post-capillary ve nules, is characteristic of Plasmodium falciparum infections. In this review, Irwin Sherman and his colleagues discuss recent advances in th e characterization of the adhesive molecules on the surface of malaria -infected erythocytes and the receptors on the endothelium to which th ey bind.