CORRELATION OF SUPERCRITICAL-FLUID EXTRACTION RECOVERIES WITH SUPERCRITICAL-FLUID CHROMATOGRAPHIC RETENTION DATA - A FUNDAMENTAL-STUDY

The possibility of using supercritical-fluid chromatographic retention data for examining the effects of operational parameters, such as pre ssure and flow rate, on the extraction characteristics in supercritica l-fluid extraction (SFE) was investigated. A model was derived for cal culating the extraction efficiency in SFE from retention data and peak shapes measured in supercritical-fluid chromatography (SFC), By perfo rming the SFC experiments at the same pressure and temperature as the SFE extractions using the SFE extraction cell as the SFC column, an ac curate prediction of extraction efficiencies could be made. Finally, t he effects of matrix composition and analyte concentration on extracti on efficiency were studied.