Xw. Lou et al., CORRELATION OF SUPERCRITICAL-FLUID EXTRACTION RECOVERIES WITH SUPERCRITICAL-FLUID CHROMATOGRAPHIC RETENTION DATA - A FUNDAMENTAL-STUDY, HRC. Journal of high resolution chromatography, 18(8), 1995, pp. 483-489
The possibility of using supercritical-fluid chromatographic retention
data for examining the effects of operational parameters, such as pre
ssure and flow rate, on the extraction characteristics in supercritica
l-fluid extraction (SFE) was investigated. A model was derived for cal
culating the extraction efficiency in SFE from retention data and peak
shapes measured in supercritical-fluid chromatography (SFC), By perfo
rming the SFC experiments at the same pressure and temperature as the
SFE extractions using the SFE extraction cell as the SFC column, an ac
curate prediction of extraction efficiencies could be made. Finally, t
he effects of matrix composition and analyte concentration on extracti
on efficiency were studied.