THERAPY OF DESMOID TUMORS, FIBROMATOSIS, AND RELATED NEOPLASMS

Forty-seven patients with unresectable desmoid tumors and 32 patients with unresectable fibromatosis were treated with various anti-neoplast ic agents including methotrexate, vinblastine, etoposide, actinomycin D, and fluorouracil. A combination of methotrexate with either vinblas tine or etoposide was found to be effective in yielding long-term cont rol to both groups of patients. Fluorouracil and actinomycin D were le ss effective. Other than a significant but slowly reversible periphera l neuropathy in 6 patients, therapy was well tolerated and no long-ter m hematologic, pulmonary, hepatic, or cardiac toxicity was noted in an y patient.