GROWTH-HORMONE TREATMENT IN NOONAN SYNDROME - REPORT OF 4 CASES WHO REACHED FINAL HEIGHT

Final height of 4 patients with Noonan syndrome and short stature trea ted with growth hormone (GH) is reported. Four prepubertal girls (chro nological age 12.3-15.1 years, bone age 11.0-11.5 years) were treated with recombinant human growth hormone (0.5 IU/kg/week s.c.) for at lea st 3 years. Stimulated GH secretion was normal, spontaneous nocturnal GH secretion was low in 1 patient. Final height, as standard deviation score according to Ranke-specific standards for Noonan syndrome, impr oved in 3 patients and 2 of them exceeded their corrected midparental height.