ANAPLASTIC LARGE-CELL KI-1 LYMPHOMA WITH BONE INVOLVEMENT - REPORT OF2 CASES

Two cases of anaplastic large cell Ki-1 lymphoma involving bone as the most prominent and initial manifestation are reported, The first pati ent was a 20-year-old male who had back pain and incomplete paraparesi s due to vertebral involvement. The second was a 14-year-old girl, who se first clinical signs were fever of unknown origin and sternal bone pain. Radiologically, skeletal lesions were lytic and destructive, His topathologically, the tumour cells had pleomorphic bizarre nuclei and abundant basophilic cytoplasm, Immunohistochemically, Ki-1(CD30) react ivity was strongly positive in both cases, Tumour cells were also CD3, CD4, epithelial membrane antigen and interleukin-2 receptor positive in the first case, and CD10, HLA-DR positive in the second case. The f ormer tumour was considered to be of T-cell lineage and the latter of lymphoid progenitor cell origin. Radiation and chemotherapy were tempo rarily effective. However, both patients died 14 and 7 months after di agnosis, respectively, due to systemic lymph node involvement, These o bservations suggest that the prognosis for Ki-1 lymphoma involving bon e is poorer than indicated in previous reports.