FERROCHELATASE BINDS THE IRON-RESPONSIVE ELEMENT PRESENT IN THE ERYTHROID 5-AMINOLEVULINATE SYNTHASE MESSENGER-RNA

Authors
FERREIRA GC
Citation
Gc. Ferreira, FERROCHELATASE BINDS THE IRON-RESPONSIVE ELEMENT PRESENT IN THE ERYTHROID 5-AMINOLEVULINATE SYNTHASE MESSENGER-RNA, Biochemical and biophysical research communications, 214(3), 1995, pp. 875-878
Citations number
21
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
214
Issue
3
Year of publication
1995
Pages
875 - 878
Database
ISI
SICI code
0006-291X(1995)214:3<875:FBTIEP>2.0.ZU;2-T
Abstract
Ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, binds an iron-responsive element (IRE) present in the 5'untranslated r egion of the mRNA for erythroid 5-aminolevulinate synthase, the first enzyme of the heme biosynthetic pathway. This IRE-binding activity of ferrochelatase may play a critical role in the regulation of heme bios ynthesis in differentiating erythrocytes. (C) 1995 Academic Press, Inc .