SYNTHESIS OF 9-CIS-RETINOIC ACID AND C-20-[(H3C)-H-3]-9-CIS-RETINOIC ACID WITH HIGH SPECIFIC ACTIVITY

Authors
TADIKONDA PK LACY JM RIGDON MG DELUCA HF
Citation
Pk. Tadikonda et al., SYNTHESIS OF 9-CIS-RETINOIC ACID AND C-20-[(H3C)-H-3]-9-CIS-RETINOIC ACID WITH HIGH SPECIFIC ACTIVITY, Journal of labelled compounds & radiopharmaceuticals, 39(1), 1997, pp. 1-10
Citations number
6
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
39
Issue
1
Year of publication
1997
Pages
1 - 10
Database
ISI
SICI code
0362-4803(1997)39:1<1:SO9AAC>2.0.ZU;2-H
Abstract
The synthesis of 9-cis-retinoic acid starting from 2,2,6-trimethylcycl ohexanone is described. The same methodology was extended for the synt hesis of deuterium and tritium labeled 9-cis-retinoic acid with high s pecific activity (73 Ci/mmol). In this methodology, a Grignard reactio n was utilized for introducing three tritium atoms simultaneously in t he final synthetic steps.