Pk. Tadikonda et al., SYNTHESIS OF 9-CIS-RETINOIC ACID AND C-20-[(H3C)-H-3]-9-CIS-RETINOIC ACID WITH HIGH SPECIFIC ACTIVITY, Journal of labelled compounds & radiopharmaceuticals, 39(1), 1997, pp. 1-10
Citations number
6
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
The synthesis of 9-cis-retinoic acid starting from 2,2,6-trimethylcycl
ohexanone is described. The same methodology was extended for the synt
hesis of deuterium and tritium labeled 9-cis-retinoic acid with high s
pecific activity (73 Ci/mmol). In this methodology, a Grignard reactio
n was utilized for introducing three tritium atoms simultaneously in t
he final synthetic steps.