QUANTITATIVE-ANALYSIS OF THE OLFACTORY PATHWAY FOR DRUG-DELIVERY TO THE BRAIN

Following intranasal administration to rats, wheat germ agglutinin-hor seradish peroxidase (WGA-HRP) concentrated in the olfactory nerve and glomerular layers of the olfactory bulb resulting in a mean olfactory bulb concentration of 140 nM. A negligible amount of label was detecte d in the olfactory bulb following intravenous administration of WGA-HR P or intranasal administration of unconjugated HRP. This is the first quantitative assessment of intraneuronal transport of a protein into t he brain using the olfactory route.