A [3-ANNULATION PROCEDURE FOR THE SYNTHESIS OF BICYCLIC METHYLENEPYRROLIDINES(2])

Authors
SADAKANE M VAHLE R SCHIERLE K KOLTER D STECKHAN E
Citation
M. Sadakane et al., A [3-ANNULATION PROCEDURE FOR THE SYNTHESIS OF BICYCLIC METHYLENEPYRROLIDINES(2]), Synlett, (1), 1997, pp. 95
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
1
Year of publication
1997
Database
ISI
SICI code
0936-5214(1997):1<95:A[PFTS>2.0.ZU;2-0
Abstract
Reactions between 2-chloromethyl-3-trimethylsilyl-1-propene 1 and N-ac yliminium ions, which were generated in situ from alpha-methoxy or alp ha-acetoxy amides 2, give allylic chlorides 3 in good yields and high stereoselectivities. The allylic chlorides 3 were further transformed to bicyclic methylenepyrrolidines 4 which are building blocks for phar macologically interesting compounds.