EFFECT OF LONG-TERM CELIPROLOL THERAPY ON HEMOSTASIS IN ESSENTIAL-HYPERTENSION

Undesirable changes of haemostasis induced by some anti-hypertensive d rugs can encourage the acceleration of atherogenesis, Therefore, the c hanges of haemostasis parameters In 22 patients with essential hyperte nsion under long-term celiprolol therapy (> 2 months) were of interest . In the placebo group of 15 essentially hypertensive patients there w ere no significant changes in platelet activity, On the other hand, th e therapeutic dose of celiprolol was shown to reduce fetal platelet ag gregation, without any harmful effects on fibrinolytic activity and co agulation inhibitors such as protein C and antithrombin III. The metab olic neutrality of celiprolol accompanied by the proven platelet-inhib itory tendency is desirable in the new approach to hypertension treatm ent. Potentially anti-thrombotic or at least neutral prothrombotic pro perties of celiprolol may be important In terms of the favourable role of anti-hypertensive drugs in cardiovascular morbidity.