Priapism is a recognised side effect of the antidepressant drug, trazo
done. In the following case we report an apparent hyper-intolerance to
a single dose of trazodone which resulted in prolonged (almost 48 hou
rs) priapism despite aggressive surgical and pharmacological intervent
ion. Although rare, the risk of such a reaction should be borne in min
d when Prescribing trazodone.