DETERMINATION OF FURAZOLIDONE IN PORCINE TISSUE USING THERMOSPRAY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY AND A STUDY OF THE PHARMACOKINETICS AND STABILITY OF ITS RESIDUES

Authors
MCCRACKEN RJ BLANCHFLOWER WJ ROWAN C MCCOY MA KENNEDY DG
Citation
Rj. Mccracken et al., DETERMINATION OF FURAZOLIDONE IN PORCINE TISSUE USING THERMOSPRAY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY AND A STUDY OF THE PHARMACOKINETICS AND STABILITY OF ITS RESIDUES, Analyst, 120(9), 1995, pp. 2347-2351
Citations number
12
Categorie Soggetti
Chemistry Analytical
Journal title
Analyst → ACNP
ISSN journal
00032654
Volume
120
Issue
9
Year of publication
1995
Pages
2347 - 2351
Database
ISI
SICI code
0003-2654(1995)120:9<2347:DOFIPT>2.0.ZU;2-D
Abstract
A method is presented for the detection of he nitrofuran, furazolidone , in porcine tissue. Following methanol-buffer extraction of the tissu e, liquid partitioning, and solid-phase clean-up, samples are analysed by using thermospray LC-MS monitoring the positive ion m/z 243 with f ilament-assisted ionization. The LOD is 1 mu g kg(-1). The assay is us ed to investigate the depletion of furazolidone from tissue and sample stability post mortem. It is necessary to snap-freeze samples by imme rsion in liquid nitrogen immediately-upon collection in order to impro ve the stability of residues in tissue.