IN-VITRO SCREENING OF TRADITIONAL MEDICINES FOR ANTIHYPERTENSIVE EFFECT BASED ON INHIBITION OF THE ANGIOTENSIN-CONVERTING ENZYME (ACE)

Citation
K. Hansen et al., IN-VITRO SCREENING OF TRADITIONAL MEDICINES FOR ANTIHYPERTENSIVE EFFECT BASED ON INHIBITION OF THE ANGIOTENSIN-CONVERTING ENZYME (ACE), Journal of ethnopharmacology, 48(1), 1995, pp. 43-51
Citations number
33
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
ISSN journal
03788741
Volume
48
Issue
1
Year of publication
1995
Pages
43 - 51
Database
ISI
SICI code
0378-8741(1995)48:1<43:ISOTMF>2.0.ZU;2-W
Abstract
Traditional medicines reported to be used as anti-hypertensives or diu retics from different regions in the world (China, India and South Ame rica) have been investigated. The bioassay is based on inhibition of A CE, as measured from the enzymatic cleavage of the chromophore-fluorop hore-labelled substrate dansyltriglycine into dansylglycine and diglyc ine. In total, 31 species have been investigated and the crude extract s from seven species inhibit the enzyme by more than 50%.