Ss. Haneef et Sk. Swarup D",kalicharan,"dwivedi, THE EFFECT OF CONCURRENT LEAD AND CADMIUM EXPOSURE ON THE CELL-MEDIATED IMMUNE-RESPONSE IN GOATS, Veterinary and human toxicology, 37(5), 1995, pp. 428-429
Cell-mediated immune response was monitored by cutaneous hypersensitiv
ity reaction (CHR) to 2-4 dinitrochlorobenzene in goats given lead or
cadmium alone or in combination. Twenty goats were divided into 4 grou
ps of 5 animals each. Group A served as control whereas Groups B, C an
d D were given po doses of 50 mg lead acetate/kg body weight, 10 mg ca
dmium chloride/kg body weight or 50 mg lead acetate/kg body weight + 1
0 mg cadmium chloride/kg body weight, respectively, for 42 d. Primary
sensitization was done on day 27 followed by a challenge dose after 14
d. Elicitation of CHR, as measured by average increase in skin thickn
ess, was suppressed significantly in goats of all dosed groups. Suppre
ssion was more in the cadmium-dosed than in the lead or lead + cadmium
dosed goats. Histopathology demonstrated reduced intensity of cellula
r reactions in the cadmium and lead + cadmium-dosed animals.