HUMAN FLUOROSIS IN MOROCCO - ANALYTICAL AND CLINICAL INVESTIGATIONS

A clinical investigation of human chronic fluorosis, known as ''Darmou s'' in Morocco, was carried out in Youssoufia city and its region. Flu oride concentrations were also measured in soil and water from this ar ea and in urine collected from the surveyed persons; soil and to a les ser extent water were rich in fluoride (948.6 +/- 356.2 mu g/g and 1.0 3 +/- 0.19 mu g/ml, respectively). Fluoride concentrations in urine we re heterogenous and varied from 0.17 to 47.5 mu g/ml. There was a good correlation between these values and the age of the sampled persons. This study revealed that 14% of the urine samples were at or above the maximum fluoride concentration in urine from non-intoxicated individu als (ie 10 mu g/ml). Dental cartes, teeth loss and teeth pigmentation and deviation were the most frequent dental effects in this area. Skel etal effects were mostly joint pa in and exostosis. With the exception of dental caries, teeth and bone abnormalities were more frequent and pronounced in people living in the rural area.