WITHIN-STRAIN AND BETWEEN-STRAIN VARIABILITY IN LONGEVITY OF INBRED AND OUTBRED RATS UNDER THE SAME ENVIRONMENTAL-CONDITIONS

Authors
GHIRARDI O COZZOLINO R GUARALDI D GIULIANI A
Citation
O. Ghirardi et al., WITHIN-STRAIN AND BETWEEN-STRAIN VARIABILITY IN LONGEVITY OF INBRED AND OUTBRED RATS UNDER THE SAME ENVIRONMENTAL-CONDITIONS, Experimental gerontology, 30(5), 1995, pp. 485-494
Citations number
27
Categorie Soggetti
Geiatric & Gerontology
Journal title
Experimental gerontology → ACNP
ISSN journal
05315565
Volume
30
Issue
5
Year of publication
1995
Pages
485 - 494
Database
ISI
SICI code
0531-5565(1995)30:5<485:WABVIL>2.0.ZU;2-P
Abstract
The analysis of 26 longevity curves of different populations of inbred (Fischer 344) acid outbred (Sprague-Dawley) rats highlighted a remark able between-populations variability in survival parameters. This vari ability is independent of the breeding characteristics of the strain. The two strains differed in the slope of the survival curves, with Fis cher 344 rats showing a higher survival over the second year of life a s well as a lower interindividual variability. A model-free approach b ased on principal component analysis allowed us to quantify these diff erences and to highlight some limitations of the classical Gompertzian approach.