DECREASED BONE-MINERAL DENSITY IN MEDICATED PSYCHIATRIC-PATIENTS

Osteoporosis is a common problem in postmenopausal women. It has been linked to estrogen deficiency, other neuroendocrine processes such as hypercortisolemia and male hypogonadism, nutritional deficiencies, and other mechanisms. Some of these changes have been also reported in ma le and female patients with mental disorders, especially those receivi ng psychotropic medications. Therefore, bone mineral density was measu red by dual-photon absorptiometry in the lumbar spine and in the femor al neck of 33 female and 35 male consenting psychiatric inpatients adm itted consecutively. Patients were diagnosed as having major depressiv e disorder (N = 21), schizophrenia (N = 33), schizoaffective disorder (N = 7), mania (N = 2), and adjustment disorder (N = 5). Plasma levels of prolactin, estrogen, cortisol, and testosterone were also measured in a subgroup of these patients. It is reported that female patients, but especially male patients, had a highly significant decrease in bo ne mineral density when compared with age- and sex-matched normal data . It is suggested that psychiatric patients treated with antidepressan ts or neuroleptics might have decreased bone mineral density than is n ormal for their age and sex, and may be at an increased risk for fract ures. These results may be related to low levels of gonadal hormones, especially in male subjects, Data should be confirmed with a larger nu mber of patients with and without medications to distinguish between d iagnosis-related and treatment-related effects.