ERM (EZRIN RADIXIN/MOESIN) FAMILY - FROM CYTOSKELETON TO SIGNAL-TRANSDUCTION/

Authors
TSUKITA S YONEMURA S TSUKITA S
Citation
S. Tsukita et al., ERM (EZRIN RADIXIN/MOESIN) FAMILY - FROM CYTOSKELETON TO SIGNAL-TRANSDUCTION/, Current opinion in cell biology, 9(1), 1997, pp. 70-75
Citations number
42
Categorie Soggetti
Cell Biology
Journal title
Current opinion in cell biology → ACNP
ISSN journal
09550674
Volume
9
Issue
1
Year of publication
1997
Pages
70 - 75
Database
ISI
SICI code
0955-0674(1997)9:1<70:E(RF-F>2.0.ZU;2-6
Abstract
The ERM family consists of three closely related proteins, ezrin, radi xin, and moesin, that are thought to work as cross-linkers between pla sma membranes and actin-based cytoskeletons. Recent ar.-lyses of the s tructure and functions of ERM proteins have revealed that these molecu les are involved not only in cytoskeletal organization but also in sig nal transduction. Furthermore, identification of the neurofibromatosis type 2 tumour suppressor, which shows striking sequence similarity to ERM proteins, has increased interest in this family.